Naprosyn is a non-steroidal anti-inflammatory drug that has anti-inflammatory, analgesic and antipyretic effects associated with non-selective inhibition of Cyclooxygenase-1 and Cyclooxygenase-2 activity.
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Product Description
The propionic acid derivative.Ithas a pronounced anti-inflammatory, analgesic and antipyretic effect.The mechanism of action of the medicine is to inhibit the migration of leukocytes, reduce the activity of lysosomes and mediators of inflammation.
It is used for in degenerative diseases of the musculoskeletal system: rheumatoid, juvenile chronic, gouty arthritis, ankylosing spondylitis, osteoarthritis.Pain syndrome: myalgia, ossalgia, neuralgia, arthralgia, sciatica, headache and toothache, tendonitis, with oncological diseases, post-traumatic and postoperative pain syndrome, accompanied by inflammation, algodismenorea, adnexitis, childbirth.Infectious and inflammatory diseases of the ENT organs with severe pain syndrome (as part of complex therapy): pharyngitis, tonsillitis, otitis media.Feverish syndrome with "colds" and infectious diseases.
Safety information
Mode of application
Intake.Tablets should be taken whole, squeezed with liquid, you can take during meals.In the acute stage of the disease - 0.5-0.75 g 2 times a day.The maximum daily dose is 1.75 g. For maintenance therapy - in an average daily dose of 500 mg for 2 divided doses (morning and night).With an acute attack of gout, the first dose is 825 mg;Then 275 mg every 8 hours. With algodismenorea - in the first dose of 500 mg, then at 275 mg every 6-8 hours for 3-4 days.With migraine, 500 mg.Rectal suppository usually prescribed for the night (1 candle 0.5 g).If necessary, the use of naproxenand, in high doses, can be combined in the appointment of candles and tablets.Children aged 1 to 5 years - in a daily dose of 2.5-5 mg/kg in 1-3 divided doses;the course of treatment should not exceed 14 days.With juvenile arthritis in children over 5 years of age, the daily dose is 10 mg/kg.A preferred dosage form for children is a suspension.
Contraindications
Hypersensitivity, erosive-ulcerative lesions of the gastrointestinal tract (in the phase of exacerbation), "aspirin" triad, oppression of bone marrow hematopoiesis, hepatic and/or renal insufficiency, pregnancy, lactation, children's age (up to 1 year). With caution of CHF, children's age (up to 16 years).
Side effects
NSAIDs-gastropathy, nausea, vomiting, epigastric discomfort, skin rash, urticaria, angioedema, headache, drowsiness, tinnitus, dizziness, weakness, slow reaction, erosive and ulcerative lesions of other digestive tract, bleeding and perforation of the gastrointestinal tract , Eosinophilic pneumonia, thrombocytopenia, granulocytopenia, aplastic anemia, hemolytic anemia;Hearing loss, impaired renal or hepatic function.
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