Sildenafil (ABHIGRA) 100 mg tablet is an inhibitor of phosphodiesterase-5 (PDE5) enzyme, which is primarily used to treat erectile dysfunction and pulmonary hypertension.
Sildenafil is a specific and effective inhibitor of cyclic guanosine monophosphate (cGMP) type 5 (PDE5) phosphodiesterase enzyme in the corpus cavernosum that induces pulmonary vascular smooth muscle cell relaxation. It replenishes reduced erectile capacity by raising blood flow to the penis; Sildenafil also requires sexual stimulation to achieve its pharmacological effects.
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Effect of the potency agent
Abhigra 100mg is used primarily to treat erectile dysfunction (impotence). The active ingredient ensures that an erection can be maintained longer. It has no lust-increasing effect and does not provide for an erection by itself. Rather, Abhigra 100mg improves men’s ability to respond to sexual arousal with an erection. Without a sexual stimulation, however, no erection is triggered.
The drug is just like tadalafil or vardenafil to the group of PDE-5 inhibitors, which have a vasodilator effect. This effect is based on the inhibition of the enzyme phosphodiesterase-5. By inhibiting the enzyme, the blood vessels in the penis relax. This facilitates the influx of blood and the erection of an erection.
Since 2006, Abhigra 100mg has also been approved as a sexual enhancer for the treatment of pulmonary hypertension (pulmonary hypertension). Again, his vasodilator effect plays a crucial role in the treatment.
Abhigra 100mg Side Effects
As with most other medications, sildenafil intake is associated with side effects. These are usually mild to moderate and will fade away after a while. For a complete list of all side effects of the drug, please refer to the package leaflet of your medication.
After taking Abhigra 100mg, the following symptoms may occur:
- a headache
- facial flushing
- stomach discomfort such as nausea, vomiting and diarrhea
- sniff
- vision problems
- dizziness
- muscle and back pain
- palpitation
- hearing impairment
- a lowered reaction
- a permanent erection
In very rare cases, a circulatory disorder of the optic nerve head (anterior ischemic optic neuropathy) was observed after ingestion. This can lead to permanent visual damage or even blindness. Whether the disorder is in a causal relationship with the intake of the drug is still unclear. If you are taking the medicine and have a decrease in vision, contact your doctor immediately and stop taking any more pills.
Abhigra 100mg Dosage
Abhigra 100mg is available in doses of 25, 50 and 100 milligrams and is administered orally.
- Normal tablets should be swallowed whole with some liquid.
- Chewable tablets are first chewed and then swallowed.
- Orodispersible tablets are placed on the tongue and swallowed only after dissolution.
How high the dose to be taken should be with you, your doctor will determine individually. In addition to the individual effectiveness and tolerability of the drug also present underlying diseases play a role. Irrespective of this, it should never be exceeded a daily dose of 100 milligrams.
The effect of the tablet begins about 30 to 60 minutes after ingestion. A luscious, greasy meal may delay the onset of action. After the effect starts, it will last for about four to five hours.
Contraindications: Caution in coronary heart disease
Abhigra 100mg must not be used concomitantly with medications containing nitrates and nitric oxide donors (for example, molsidomine). Otherwise, it can lead to a significant increase in the effectiveness of these drugs.
It should also be noted that patients with coronary heart disease should take the drug only after consulting their doctor. For them, the stress of intercourse can increase the risk of overuse of the circulation. Likewise, the use is contraindicated in severe liver damage and an allergy to the drug.
In addition, Abhigra 100mg should only be taken with particular care in the following conditions: leukemia, peptic ulcer, multiple myeloma, sickle cell anemia, blood clotting disorder. Likewise, if you have a disease or deformity of your penis, you should consult your doctor before taking it.
Interactions with other drugs
Taking sildenafil may result in a number of drug-drug interactions. Affected are primarily drugs that are metabolized with the participation of the same enzymes as the power means:
- ketoconazole
- itraconazole
- erythromycin
- cimetidine
- ritonavir
- saquinavir
Interactions with alpha-blockers may also interact: in some cases, side effects such as drowsiness and dizziness have occurred. However, this can usually be prevented by increasing the time between receipts.
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Cialis Soft Tabs differs from a usual tablet of Cialis in the fact that its action comes quicker. Cialis Soft is chewed and dissolved under a tongue that allows to reach a required effect in 10-15 minutes. Important!!! Cialis Soft is compatible to alcohol and greasy food!
Cialis is a latest medicine for treatment of disturbances of erection at men. Sialis's feature is its high-speed performance (30 minutes) and a long-term effect (up to 36 hours). In this regard you can choose the moment which is most suitable for sexual intercourse, having accepted a drug in advance. It is possible to take Sialis in the morning and to be ready even next day. Active ingredient - Tadalafil, the recommended dosage - 20 mg.
Actos, which is pioglitazone - is prescribed to patients with diabetes of type 2 (both as monotherapy, and in a form of the combined therapy with sulphonylurea, metformin or insulin as additional medicine to dietotherapy and physical exercises). Pioglitazone represents peroral hypoglycemic medicine of Thiazolidinediones alignment which effect depends on insulin presence. It is a high-selective agonist of gamma receptors, activated by proliferator of peroxysom (PPAR-γ).
Avapro - the remedy which is used separately or in combination with other drugs for treatment of high blood pressure. It is also used for treatment of diseases of kidneys caused by diabetes mellitus 2 type (the state at which the organism can't use insulin normally and, therefore, can't control amount of sugar in blood) and high blood pressure. Irbesartan in a class of the drugs called antagonists of receptors of angiotensin II. It works by blocking of effects of some natural substances which tighten blood vessels that allows blood flow more smoothly and the heart works more effectively.
Celexa - antidepressant. Brings energy, stops feeling of alarm, reduces sensation of fear and tension, eliminates dysphoria, reduces persuasive feelings, practically does not cause sedation. The lasting clinical effect develops in 7-10 days of regular reception. The mechanism of action is connected with selective blockade of the return neuronal serotonin reuptake in synapses of neurons of CNS with a minimum effect concerning reuptake of noradrenaline and dopamine.
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"Loop" diuretic, used for edematous syndrome with CHF II-III st., liver cirrhosis, kidney disease; swelling of the lungs or brain; arterial hypertension, hypercalcemia. Causes a rapidly advancing, strong and short-term diuresis. Has natriuretic and chlororetic effects, increases the excretion of K +, Ca2 +, Mg2 +.
Mobic is a nonsteroidal anti-inflammatory drug, which has anti-inflammatory, antipyretic, analgesic effect. It belongs to the class of oxicams; derived from the anoliefo acid. Used in symptomatic treatment of osteoarthritis, rheumatoid arthritis, ankylosing spondylitis (Bekhterev's disease) and other inflammatory and degenerative diseases, accompanied by pain syndrome.
Septra - Sulfamethoxazole is an antibiotic that treats various types of infections caused by bacteria. The combination of sulfamethoxazole and trimethoprim is used to treat ear infection, urinary tract infection, prostate infection, bronchitis, travelers' diarrhea and pneumocystis pneumonia. The drug is available in the form of tablets, as well as in liquid form.
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Dutas is a mix of two medicines: dutasteride and tamsulosin hydrochloride. The drugs have complementary mechanisms of action, due to which there is a rapid weakening of urination. It reduces the risk of retention of the urine. It is not anticipated that the pharmacodynamic reactions of a fixed dosage mix of dutasteride-tamsulosin differ from those obtained with the simultaneous use of dutasteride and tamsulosin as separate elements. Dutasteride inhibits the activity of both the 1st and 2nd type of isoenzymes. DHT is an androgen that is responsible for prostate and the increase of BPH. It inhibits the activity of adrenoreceptors.
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