Free Shipping on All orders Over $200!
stock-banner
Only In October
10% off
orders over $222

Use promo code HAPPY on your most loved items!

stock-banner
Only In October
FREE bonus
Pills for every order

Free Shipping on orders Over $200!

stock-banner
Only In October
Free Shipping
on All orders Over $200!

Free Shipping on orders Over $200!

Search by name:
All A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Other
Besivance Ophthalmic Solution 0.6 %
Besivance Ophthalmic Solution 0.6 %
Active ingredient: Besifloxacin

Besivance is a medicine used to treat the symptoms of Bacterial Conjunctivitis.

Besivance may be used alone or with other medications.

Besivance belongs to a class of drugs called Quinolones, Ophthalmic.

It is not known if Besivance is safe and effective in children younger than 1 year of age.

We accept: visa mastercard sepa bitcoin ethereum
October
14
airmail
Delivery period
14-21 days
$9.95
Tracking# available in 14 days
ems
Delivery period
14-21 days
$29.95
Tracking# available in 5 days
Availability:In Stock 105 packs
Besivance Ophthalmic Solution 0.6 % 5
Package Per pill Total price Save Order
5 x 1 Flacons $24.26
$24.26
- Add to cart
5 x 2 Flacons $23.83
$47.66
$0.86 Add to cart
5 x 3 Flacons $20.99
$62.96
$9.81 Add to cart
5 x 4 Flacons $20.47
$81.86
$15.16 Add to cart
5 x 5 Flacons $18.71
$93.56
$27.75 Add to cart
Package Example

Your order will be packed safe and secure and dispatched within 24 hours. This is exactly how your parcel will look like (pictures of a real shipping item). It has a size and a look of a regular private letter (9.4x4.3x0.3 inches or 24x11x0.7cm) and it does not disclose its contents

Front View
package-front
Side View
package-side
Back View
package-back
Storage

Store at 15°- 25°C (59°- 77°F). Protect from light.

Safety information


Warnings

Not For Injection Into The Eye

Growth Of Resistant Organisms With Prolonged Use

As with other anti-infectives, prolonged use of BESIVANCE (besifloxacin ophthalmic suspension) 0.6% may result in overgrowth of non-susceptible organisms, including fungi. If super-infection occurs, discontinue use and institute alternative therapy. Whenever clinical judgment dictates, the patient should be examined with the aid of magnification, such as slitlamp biomicroscopy, and, where appropriate, fluorescein staining.

Avoidance Of Contact Lenses

Patients should not wear contact lenses if they have signs or symptoms of bacterial conjunctivitis or during the course of therapy with BESIVANCE.

Nonclinical Toxicology

Carcinogenesis, Mutagenesis, Impairment Of Fertility

Long-term studies in animals to determine the carcinogenic potential of besifloxacin have not been performed.

No in vitro mutagenic activity of besifloxacin was observed in an Ames test (up to 3.33 mcg/plate) on bacterial tester strains Salmonella typhimurium TA98, TA100, TA1535, TA1537 and Escherichia coli WP2uvrA. However, it was mutagenic in S. typhimurium strain TA102 and E. coli strain WP2 (pKM101). Positive responses in these strains have been observed with other quinolones and are likely related to topoisomerase inhibition.

Besifloxacin induced chromosomal aberrations in CHO cells in vitro and it was positive in an in vivo mouse micronucleus assay at oral doses ≥ 1,500 mg/kg. Besifloxacin did not induce unscheduled DNA synthesis in hepatocytes cultured from rats given the test compound up to 2,000 mg/kg by the oral route.

In a fertility and early embryonic development study in rats, besifloxacin did not impair the fertility of male or female rats at oral doses of up to 500 mg/kg/day. This dose is approximately 26,500 times higher than the mean plasma concentration measured in humans at the recommended human ophthalmic dose.

Use In Specific Populations

Pregnancy

Risk Summary

There are no available human data for the use of BESIVANCE during pregnancy to inform any drug-associated risks; however, systemic exposure to besifloxacin from ocular administration is low.

Oral administration of besifloxacin to pregnant rats during organogenesis or during the pre/postnatal period did not produce adverse embryofetal or offspring effects at clinically relevant systemic exposures.

Data

Animal Data

In an embryofetal development study in rats, the administration of besifloxacin at oral doses up to 1,000 mg/kg/day during organogenesis was not associated with visceral or skeletal malformations in rat fetuses, although this dose was associated with maternal toxicity (reduced body weight gain and food consumption) and maternal mortality. Increased post-implantation loss, decreased fetal body weights, and decreased fetal ossification were also observed. At this dose, the mean Cmax in the rat dams was approximately 20 mcg/mL, approximately 46,500 times the mean plasma concentrations measured in humans at the recommended human ophthalmic dose (RHOD). The No Observed Adverse Effect Level (NOAEL) for this embryofetal development study was 100 mg/kg/day (Cmax, 5 mcg/mL, approximately 11,600 times the mean plasma concentrations measured in humans at the RHOD).

In a prenatal and postnatal development study in rats, the NOAELs for both fetal/neonate and maternal toxicity were 100 mg/kg/day. At 1,000 mg/kg/day, pups weighed significantly less than controls and had a reduced neonatal survival rate. Attainment of developmental landmarks and sexual maturation was delayed, although surviving pups from this dose group that were reared to maturity did not demonstrate deficits in behavior, including activity, learning and memory, and their reproductive capacity appeared normal.

Lactation

Risk Summary

There are no data on the presence of BESIVANCE in human milk, the effects on the breastfed infant, or the effects on milk production. However, systemic exposure to besifloxacin following topical ocular administration is low, and it is not known whether measurable levels of besifloxacin would be present in maternal milk following topical ocular administration.

The developmental and health benefits of breastfeeding should be considered, along with the mother’s clinical need for BESIVANCE, and any potential adverse effects on the breastfed infant from BESIVANCE.

Pediatric Use

The safety and effectiveness of BESIVANCE in infants below one year of age have not been established. The efficacy of BESIVANCE in treating bacterial conjunctivitis in pediatric patients one year or older has been demonstrated in controlled clinical trials. There is no evidence that the ophthalmic administration of quinolones has any effect on weight bearing joints, even though systemic administration of some quinolones has been shown to cause arthropathy in immature animals.

Geriatric Use

No overall differences in safety and effectiveness have been observed between elderly and younger patients.

Disclaimer

The information on this page is not intended to be a substitute for professional medical advice. Do not use this information to diagnose or treat your problem without consulting your doctor.

Side effects


Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in clinical practice.

The data described below reflect exposure to BESIVANCE in approximately 1,000 patients between 1 and 98 years old with clinical signs and symptoms of bacterial conjunctivitis.

The most frequently reported ocular adverse reaction was conjunctival redness, reported in approximately 2% of patients.

Other adverse reactions reported in patients receiving BESIVANCE occurring in approximately 1-2% of patients included: blurred vision, eye pain, eye irritation, eye pruritus and headache.

Recently viewed
Erectile Dysfunction

Cialis Soft Tabs differs from a usual tablet of Cialis in the fact that its action comes quicker. Cialis Soft is chewed and dissolved under a tongue that allows to reach a required effect in 10-15 minutes. Important!!! Cialis Soft is compatible to alcohol and greasy food!

Cialis Soft Tabs Cialis Soft Tabs
$0.92
Per pill
Add to cart
Bestsellers
Erectile Dysfunction

Cialis Oral Jelly (Orange) - a new formula of Cialis which you can have, without washing down with water. Against background of ordinary drug it differs in increased influence speed. It is prescribed for improvement of sexual endurance of men during intimate proximity. It simplifies the excitative process of penis and strengthens erection. Noticeably increases duration of sexual intercourse. Besides, the drug possesses a pleasant orange flavor.

Cialis Oral Jelly (Orange) Cialis Oral Jelly (Orange)
$2.84
Per pill
Add to cart
Today’s sale
Erectile Dysfunction

Viagra - Active ingredient - Sildenafil, 100 mg. Effect of "Viagra" is based on significant increase of blood stream to penis. Begins to work in 30 minutes, the effect lasts for 4-5 hours. Most of men can take this generic viagra every day. Millions of men worldwide cannot be mistaken, choosing Viagra!

Viagra Viagra
$0.24
Per pill
Add to cart
Erectile Dysfunction

Viagra - Active ingredient - Sildenafil, 100 mg. Effect of "Viagra" is based on significant increase of blood stream to penis. Begins to work in 30 minutes, the effect lasts for 4-5 hours. Most of men can take this generic viagra every day. Millions of men worldwide cannot be mistaken, choosing Viagra!

Viagra Viagra
$0.24
Per pill
Add to cart
Erectile Dysfunction

Cialis Oral Jelly (Orange) - a new formula of Cialis which you can have, without washing down with water. Against background of ordinary drug it differs in increased influence speed. It is prescribed for improvement of sexual endurance of men during intimate proximity. It simplifies the excitative process of penis and strengthens erection. Noticeably increases duration of sexual intercourse. Besides, the drug possesses a pleasant orange flavor.

Cialis Oral Jelly (Orange) Cialis Oral Jelly (Orange)
$2.84
Per pill
Add to cart
Erectile Dysfunction

Brand Viagra - a drug from Pfizer, with a basic chemical called Sildenafil Citrate, is a first developed pharmaceutical to cure the difficulties with erection. It functions approximately within 4-5 hours, must be taken an hour prior to sex.

Brand Viagra Brand Viagra
$1.59
Per pill
Add to cart
advantages
Free Regmail
All Orders From $200
*Limited Time Offer
advantages
Free ems Regmail
All Orders From $200
*Limited Time Offer
advantages
1m+ Customers
Quality, Privacy, Secure.
advantages
Very Low Prices
Best price in the world!
advantages
Fast Delivery
100% Guarantee. Free Airmail shipping.