Glucophage - guanyl guanidine, hypoglycemic medicine for peroral takein. At patients with a diabetes mellitus reduces concentration of glucose in blood by oppression of gluconeogenesis in a liver, reduction of absorption of glucose from GIT and increase of its utilization in tissues. Stabilizes or reduces a body weight.
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Glucophage Product Description
Drug Uses
Glucophage is a hypoglycemic drug for oral use, belonging to the group of biguanides. Glucophage is used in the management of type 2 diabetes in pediatric overweight patients aged 10 years and older, and in overweight or obese adults.
Glucophage is prescribed to diabetic patients as an adjunct, when diet and physical activity are unable to regulate blood glucose level. This antihyperglycemic drug reduces glucose production by the liver and its intestinal absorption.
Clinical studies have shown that maintenance of normal blood glucose levels reduces the risk of diabetic complications (such as vision loss or eye disease, cardiovascular diseases). The recommended starting dose of Glucophage for adults is 850 to 1000 mg per day. The maximum daily dose should not exceed 2000mg of the antihyperglycemic drug.
Due to the reduction of renal activity in elderly patients and high risk of lactic acidosis, use of Glucophage should start with small doses of this antihyperglycemic drug, and titration should be made with caution. The initial daily dose of Glucophage for children is 500 mg in the morning and in the evening, with a maximum dose of 2000 mg.
Missed Dose
If you remember that you have missed a dose of Glucophage, take it with food as soon as you can, except when the time is approaching for taking the next dose of the oral antihyperglycemic agent. Then you should just skip one Glucophage dose, without doubling the following.
More Information
Glucophage hypoglycemic drug may be administered in combination with insulin or with other oral antidiabetic agents for the treatment of diabetes in obese adults. Glucophage is recommended as monotherapy or in combination with insulin for the treatment of obese children and adolescents. The patient is recommended to stop taking the antihyperglycemic drug Glucophage in the first symptoms of lactic acidosis (upset stomach, low blood pressure, slow heartbeat).
Storage
To protect the tablets from moisture and light, it is recommended to store Glucophage in an original light-resistant container. The optimum storage temperature for Glucophage tablets ranges from 20°C to 25°C.
Glucophage Safety Information
Warnings
It is recommended to stop taking Glucophage, if an intercurrent disease (congestive heart failure, hepatic dysfunction, or myocardial infarction) is observed in patient during the antihyperglycemic therapy. Prolonged use and high doses of the antihyperglycemic drug Glucophage may cause a violation of vitamin B12 absorption and lead to diseases, caused by lack of this vitamin in the body. To avoid them, measurement of hematologic parameters and prevention of subnormal vitamin B12 levels are recommended during the treatment.
Disclaimer
All information on hyperglycemia, provided in the review on Glucophage, is for information purposes only and can not be viewed as a substitute for professional advice of a health care specialist. We disclaim all liability for loss, claims and damages, resulting from improper use of materials on oral antihyperglycemic agent Glucophage.
Glucophage Side Effects
During the research test, conducted in the United States, the adverse reactions, registered in treatment with Glucophage, have been reported by more than 5% of patients. In the treatment with Glucophage, children of 10 years and above have the same adverse effects, as adults.
The most common adverse reactions manifest in the beginning of therapy with Glucophage. These include gastrointestinal disorders, like vomiting, diarrhea, loss of appetite and nausea. Some frequent adverse reactions, seen in the treatment with Glucophage, manifest after the drug use is discontinued. Such adverse reactions include abdominal pain, dyspepsia, abdominal distention, flatulence.
Glucophage may also cause other, less frequent, adverse reactions, like dyspnea, chills, hypoglycemia, taste disorder, flushing, myalgia, nail disorder, chest discomfort, palpitation, abnormal stools, rash, and taste disturbance.
Aceon, which is perindopril - is prescribed at hypertensia, stroke prevention, chronic cardiac failure. Medicine has a vasorelaxant action, it reduces an afterload due to TPR relief, the medicine reduces resistance in vessels of lungs. It is observed increase of the minute volume of myocardium and increase tolerance of myocardium to strain. The medicine has the natriuretic effect and cardioprotection action. The effect of hypotension is observed in 60 minutes after taking the medicine. Arterial pressure loss isn't followed by development of tachycardia. The maximum therapeutic effect is observed in 4-8 hours, the effect is long-term (up to 24 hours). Perindopril improves brain, kidneys, and myocardium circulation, it reduces the needs of cardiomyocytes for oxygen at CHD.
Cialis Soft Tabs differs from a usual tablet of Cialis in the fact that its action comes quicker. Cialis Soft is chewed and dissolved under a tongue that allows to reach a required effect in 10-15 minutes. Important!!! Cialis Soft is compatible to alcohol and greasy food!
Cialis is a latest medicine for treatment of disturbances of erection at men. Sialis's feature is its high-speed performance (30 minutes) and a long-term effect (up to 36 hours). In this regard you can choose the moment which is most suitable for sexual intercourse, having accepted a drug in advance. It is possible to take Sialis in the morning and to be ready even next day. Active ingredient - Tadalafil, the recommended dosage - 20 mg.
Actos, which is pioglitazone - is prescribed to patients with diabetes of type 2 (both as monotherapy, and in a form of the combined therapy with sulphonylurea, metformin or insulin as additional medicine to dietotherapy and physical exercises). Pioglitazone represents peroral hypoglycemic medicine of Thiazolidinediones alignment which effect depends on insulin presence. It is a high-selective agonist of gamma receptors, activated by proliferator of peroxysom (PPAR-γ).
In case of an arterial hypertension of Atacand causes dose-dependent long lowering of arterial pressure. Anti-hypertensive action happens due to decrease in system peripheric resistance without reflex increase in heart rate. Instructions on serious or strengthened hypotension after taking of the first dose or Withdrawal Effect after termination of treatment are absent.
Augmentin - the Antibiotic of a broad spectrum of activity. It has bacterolytic (destroying bacteria) effect. It is active concerning a wide range of aerobic and anaerobic gram-positive and aerobic gramnegative microorganisms, including strains producing betalactamase. It is prescribed at diagnosing of bacterial infections caused by microorganisms, sensitive to drug: infections of upper respiratory tracts, bacterial infections of skin and soft tissues, infections of urogenital tract, sepsis, infection pelvic organs.
Avapro - the remedy which is used separately or in combination with other drugs for treatment of high blood pressure. It is also used for treatment of diseases of kidneys caused by diabetes mellitus 2 type (the state at which the organism can't use insulin normally and, therefore, can't control amount of sugar in blood) and high blood pressure. Irbesartan in a class of the drugs called antagonists of receptors of angiotensin II. It works by blocking of effects of some natural substances which tighten blood vessels that allows blood flow more smoothly and the heart works more effectively.
Capoten suppresses activity of angiotensin-converting-enzyme therefore angiotensin-I turns into angiotensin II - substance which has strong vasoconstrictive action. Capoten reduces secretion of Aldosteronum in suprarenal cortex, at the same time the delay of sodium and water in an organism decreases. Capoten slows down process of bradykinin destruction and promotes increase of E2 prostaglandin, and also nitrogen oxide that causes vasodilating action. Thanks to these effects it is decreased the increased arterial pressure, the general peripheric resistance decreases, pressure in the right auricle, in a small circle of blood circulation decreases and cordial emission increases.
Celexa - antidepressant. Brings energy, stops feeling of alarm, reduces sensation of fear and tension, eliminates dysphoria, reduces persuasive feelings, practically does not cause sedation. The lasting clinical effect develops in 7-10 days of regular reception. The mechanism of action is connected with selective blockade of the return neuronal serotonin reuptake in synapses of neurons of CNS with a minimum effect concerning reuptake of noradrenaline and dopamine.
Etodolac - has an anti-inflammatory, analgesic, antipyretic effect. The medicine is prescribed in case of rheumatoid arthritis, ankylosing spondylitis, arthrosis with pain syndrome and restriction of movements, acute and chronic osteoarthritis.
Eulexin - antineoplastic medicine, anti-androgen. Competitively blocks interaction of androgens with their cellular receptors; interferes with manifestation of biological effects of male sex hormones in androgensensetive organs. It is taken for palliative treatment of cancer.
Hydrea - antineoplastic medicine, antimetabolite, slows down DNA synthesis. It is used for treatment of acute and chronic myelogenous leukemia, osteomyelofibrosis, erythremia, essential thrombocythaemia, thrombocytosis associated with myeloproliferative syndrome, lymphogranulomatosis, melanoma, ovarian cancer, horionepitelioma of uterus, tumor of the head and the neck, tumor of brain, an acute lymphoblastic leukosis at children, a colon cancer, a prostate cancer, cancer of a lung, cancer of a neck of uterus (for increase in efficiency of radiation therapy).
"Loop" diuretic, used for edematous syndrome with CHF II-III st., liver cirrhosis, kidney disease; swelling of the lungs or brain; arterial hypertension, hypercalcemia. Causes a rapidly advancing, strong and short-term diuresis. Has natriuretic and chlororetic effects, increases the excretion of K +, Ca2 +, Mg2 +.
Lipitor refers to inhibitors of hydroxymethylglutaryl coenzyme A-reductase. It is used to lower the level of LDL cholesterol (bad cholesterol) in the blood, total cholesterol, triglycerides (another kind of fat) and apolipoprotein B (protein required for cholesterol production). Lipitor is also used to increase the blood cholesterol level of HDL cholesterol (good cholesterol). It is necessary to reduce the risk of hardening of the arteries, which can lead to heart attacks, strokes and peripheral vascular diseases.
Mobic is a nonsteroidal anti-inflammatory drug, which has anti-inflammatory, antipyretic, analgesic effect. It belongs to the class of oxicams; derived from the anoliefo acid. Used in symptomatic treatment of osteoarthritis, rheumatoid arthritis, ankylosing spondylitis (Bekhterev's disease) and other inflammatory and degenerative diseases, accompanied by pain syndrome.
An anthelmintic broad-spectrum drug; most effective with enterobioze and trihozefaleze. Causes irreversible violation of glucose utilization, depletes the glycogen stores in the tissues of worms, inhibits the synthesis of cellular tubulin and also inhibits the ATP synthesis.
An oral hypoglycemic means, which inhibiting the intestinal alpha-glycosidase, reduces the enzymatic conversion of di-, oligo - and polysaccharides to mono-saccharides, thereby reducing the absorption of glucose from the intestine and postprandial hyperglycemia. It is used to treat diabetes, of type 2 under the ineffective diet, the course of which shall not be less than 6 months, type 1diabetes within the combination therapy.
Septra - Sulfamethoxazole is an antibiotic that treats various types of infections caused by bacteria. The combination of sulfamethoxazole and trimethoprim is used to treat ear infection, urinary tract infection, prostate infection, bronchitis, travelers' diarrhea and pneumocystis pneumonia. The drug is available in the form of tablets, as well as in liquid form.
Zovirax in the form of a cream for external use is prescribed for the treatment of infections of the skin and mucous membranes caused by the herpes simplex virus type 1 and 2, including herpes lips. Eye ointment is used for keratitis caused by the herpes simplex virus type 1 and 2. Zovirax inside and in the form of a solution for infusion is used in the presence of herpes zoster and chicken pox;
Indications for taking Zovirax in the form of tabletsis a:treatment of infections of the mucous membranes and skin caused by the herpes simplex virus type 1 and 2, including genital herpes; treatment of patients with severe immunodeficiency (mainly, with the expanded clinical picture of AIDS, with HIV infection), who underwent bone marrow transplantation.
Sildalist - sildenafil plus tadalafil tablet, a preparation manufactured by Cipla Inc. One red colored rectangular pill is equivalent to 1 pill of sildenafil100mg and 1 pill of tadalafil 20mg mixed together. This is the most potent product to stop erectile malady. The task of Sildalist tablets is to make penis ready for a sex as soon as the user comes into a state of sexual arousal.
Fincar - Cipla product, the main component of which is oriented to relieve the symptoms of the prostate enlargement - a malady during which a resized prostate results in a feeling of pain when urinating). The outcome from this medical agent is grounded on the lessening of the level of dihydrotestosterone in the male organism.
Dutas is a mix of two medicines: dutasteride and tamsulosin hydrochloride. The drugs have complementary mechanisms of action, due to which there is a rapid weakening of urination. It reduces the risk of retention of the urine. It is not anticipated that the pharmacodynamic reactions of a fixed dosage mix of dutasteride-tamsulosin differ from those obtained with the simultaneous use of dutasteride and tamsulosin as separate elements. Dutasteride inhibits the activity of both the 1st and 2nd type of isoenzymes. DHT is an androgen that is responsible for prostate and the increase of BPH. It inhibits the activity of adrenoreceptors.
Gasex arranges the work of the intestine and reduces the time of digestion process. The drug acts as spasmolytic, antiulcerant, anti-inflammatory agent, cholagogue, hepatoprotective agent, membrane-modulating agent, an antimicrobial agent, and antioxidant. The drug also improves the digestibility of vitamins. It’s used for symptomatic control and relief of dyspepsia (upset stomach). The drug is used in case of flatulence, bloating, belching and for preliminary radiographic preparation of the intestine for radiography. The pills cope with discomfort in the abdomen in the postoperative period or during prolonged immobilization.
An antifungal agent from the group of imidazole derivatives for external and local applications reduces the synthesis of ergosterol, which is a part of the cell membrane of the microbial wall and leads to a change in its structure and properties. In fungicidal concentrations, it interacts with mitochondrial and peroxidase enzymes, leading to an increase in the concentration of hydrogen peroxide to toxic levels, which also contributes to the destruction of fungal cells. The pills are active against pathogenic dermatophytes, pathogens of multi-colored lichen, erythrasma, gram-positive and gram-negative bacteria.
Tadapox includes two medications combined for an even more effective approach of the problem of erectile dysfunction. The first one, Tadalafil, is a mighty restorative agent that reverses a male’s inability to achieve a satisfyingly firm erection. The second component, Dapoxetine, handles the other side of clinical impotency that shows as untimely ejaculation. Tadapox successfully manages said issues in populations of patients from 18 to 64 years of age. Its unique mix of therapeutic characteristics helps men revitalize their sexual function in a comparatively short time.
Zyvox is a synthetic medicine with the increased antibacterial effectiveness. It is mostly used in the treatment of pulmonary and skin diseases caused by a wide range of Gram-positive species. In current medicinal practice, Zyvox often plays a role of the drug of last resort, since it is intended for use in people suffering from multidrug-resistant infections. The extremely high efficiency of this medicine makes it a popular choice in the treatment of severe bacterial infections and simultaneously limits its use against low-hazard infections in order to avoid propagation of resistant microorganisms.
Sildenafil (ABHIGRA) 100 mg tablet is an inhibitor of phosphodiesterase-5 (PDE5) enzyme, which is primarily used to treat erectile dysfunction and pulmonary hypertension.
Sildenafil is a specific and effective inhibitor of cyclic guanosine monophosphate (cGMP) type 5 (PDE5) phosphodiesterase enzyme in the corpus cavernosum that induces pulmonary vascular smooth muscle cell relaxation. It replenishes reduced erectile capacity by raising blood flow to the penis; Sildenafil also requires sexual stimulation to achieve its pharmacological effects.
Tadalafil is phosphodiesterase type 5 inhibitor and has similar actions to the other phosphodiesterase type 5 inhibitors such as Sildenafil Citrate.