Tadacip - an Indian brand, whose main chemical element is tadalafil, which is also a principal part of Cialis pills. It's been created by Cipla Ltd. with a more lucrative cost in comparison to Cialis made by the brand-maker Eli Lilly.

Tadalis SX - a marvelous Indian brand from Ajanta, which is used to get rid of sexual disorders in the stronger sex. Based on the same main ingredient as the famous Cialis, Tadalis SX provides the man with a sexual strength and stamina for all 36 hours.

Tadapox includes two medications combined for an even more effective approach of the problem of erectile dysfunction. The first one, Tadalafil, is a mighty restorative agent that reverses a male’s inability to achieve a satisfyingly firm erection. The second component, Dapoxetine, handles the other side of clinical impotency that shows as untimely ejaculation. Tadapox successfully manages said issues in populations of patients from 18 to 64 years of age. Its unique mix of therapeutic characteristics helps men revitalize their sexual function in a comparatively short time.

Tadalafil is phosphodiesterase type 5 inhibitor and has similar actions to the other phosphodiesterase type 5 inhibitors such as Sildenafil Citrate.

Tadora is a relatively new medicine designed for prevention of the erectile failure. It contains the same active ingredient as the majority of other drugs used in current medicinal practice – Tadalafil, though its mechanism of action is not identical. The main difference, which is simultaneously the main advantage of the medicine, is its prolonged half-life. It is often called a “weekend pill” because it may work for 36-48 hours, creating favorable conditions for a normal intercourse. It can be recommended for men suffering from various forms of impotence, especially those requiring prolonged therapeutic action.

Tegretol - anticonvulsant drug, dibenzodiazepine derivative. It also has neurotropic and psychotropic action. Indications for use: epilepsy, alcohol withdrawal syndrome, idiopathic trigeminal neuralgia and trigeminal neuralgia with multiple sclerosis (typical and atypical), idiopathic neuralgia of the glossopharyngeal nerve, diabetic neuropathy with pain syndrome, diabetes insipidus of central genesis,

is given to patients for treating severe acne that do not respond to other medicines

Tenorminis a cardioselective beta-adrenoblocker. It is based on a substance called Atenolol, which blocks nerve impulses, which leads to a decrease in the frequency and strength of the heartbeat. Atenolol has antihypertensive (lowers pressure), antianginal (eliminates the symptoms of myocardial ischemia) and antiarrhythmic (eliminates heart rhythm disturbances) by action.

Teramycin acts depressingly on pathogens of many diseases, as well as biomycin. It is less toxic and longer preserves its action in the body. The medicine is used for the treatment of anthrax, teileriosis, cholera and pasteurellosis and other diseases.

Tetracycline has a wide range of antibacterial activity. It interferes with the formation of a complex between the transport RNA and the ribosome, which leads to a violation of protein synthesis by a microbial cell. Active in relation to most gram-positive and gram-negative bacteria, spiophets, leptospires, rickettsiaes, trachomae pathogens, ornithosis, and large viruses.

Thorazine - the product of GlaxoSmithKline and Zuellig Pharma, based on the Chlorpromazine, the substance which belongs to a neuroleptic group of aliphatic derivatives of phenothiazine. It has a pronounced antipsychotic effect, eliminates psychomotor agitation, reduces fear, aggressiveness, psychomotor inhibition. In addition to neuroleptic and sedative, it has antiemetic, hypothermic, antihypertensive, antihistamine and antiserotonin effect. It blocks central adrenergic and dopaminergic interneural contacts. Potentsiruet action of analgesics, local anesthetics, hypnotics and anticonvulsants.

Tinidazole - an antibacterial agent for systemic intake, used for the treatment of diseases such as trichomoniasis, giardiasis, amoeba dysentery, anaerobic infection, mixed aerobic-anaerobic infections (in combination with appropriate antibiotics), prevention of postoperative anaerobic infections.

Zanaflex (tizanidine) - the drug with an antispastic effect in increased muscle tone, relieves spasms and clonic convulsions.

Assign with painful muscular spasms associated with static and functional spine lesions (cervical and lumbar syndrome), and after surgery for a herniated disc or osteoarthritis of the thigh, as well as for spasms and pain due to multiple sclerosis, chronic myelopathy, degenerative diseases of the spinal cord brain, stroke, with cramps of central origin.

Tofranil is a drug that is very sensitive to the form of depressive disorder (glycoem depressive disorder, depressive phase of bipolar infections, depressive disorder, migraine, depression, dysthymia;

The main effect of Top Avana lies in the sustainment of a sexually productive penile erection. Its extra benefit in males consists in a significant enlargement of the coitus and postponement of ejaculations. The drug’s component Avanafil inhibits the body chemical preventing an ED patient from getting an erection. Avanafil enzymatically enhances the circulation and lets the corpus cavernosum stay pumped with blood.

Topamax - the remedy with an active ingredient: topiramate, it is used as a monotherapy for the treatment of adults and children 6 years of age with partial attacks with or without secondary generalized seizures and primary generalized tonic-clonic seizures; as an adjunct therapy for the treatment of adults and children 2 years of age with partial attacks with or without secondary generalized seizures or primary generalized tonic-clonic seizures and the treatment of attacks associated with Lennox-Gasto syndrome; to prevent migraine attacks in adults, after careful evaluation of alternative treatment options. Topiramate is not recommended for the treatment of acute conditions.

Toradol - tablets containing 5 and 10 mg of ketorolac tromethamine as an active substance. It has a pronounced analgesic, as well as antipyretic and anti-inflammatory action, the mechanism of which is associated with inhibition of the synthesis of prostaglandins. Suppresses the aggregation of platelets.

Tramadol (Ultram) is a narcotic-like pain reliever used to treat moderate to severe pain, its extended-release is used to treat moderate to severe chronic pain when treatment is needed around the clock.

Trandate - pills, mainly used in hypertension, it is an ideal means for lowering blood pressure.The rapid action of the active substance, Labetalol, distinguishes the drug from other similar drugs according to indications. The drug has the fastest antihypertensive effect.

Trazodone is an antidepressant, a thiazolopyridine derivative. It also has a timoleptic, anxiolytic, sedative and miorelaxing action. Has a high affinity for some subtypes of serotonin receptors, inhibits the reuptake of serotonin; The neuronal capture of norepinephrine and dopamine affects little.

Trecator SC - an anti-TB drug (antituberculous), contains Ethionamide as a basic substance, the drug is prescribed for the treatment of multidrug-resistant type of tuberculosis, with the mycobacterium tuberculosis susceptible to it.

Trental - is an angioprotector, which improves blood microcirculation. It is prescribed for the treatment of circulatory disorders of various etiologies.

Tricor - is a hypolipidemic agent, has an uricosuric and antiplatelet effect. In combination with diet therapy, the drug is prescribed for a long-term treatment, the effectiveness of which must be periodically checked by determining serum lipid levels.

Trileptal is used to treat simple and complex forms of partial epileptic seizures that have secondary generalization (possibly without it) beginning at the age of one month; generalized tonic-clonic forms of epileptic seizures in patients from two years of age. Reviews about Trileptal have a positive connotation, which allows to determine its effectiveness in use, thanks to patients who have experience of taking the drug.

Trimox has an active ingredient called amoxicillin. It is an antibiotic of penicillin, which fights bacteria. Trimox is used to treat many different types of infection caused by bacteria such as tonsillitis, bronchitis, pneumonia, gonorrhea and infections of the ear, nose, throat, skin or urinary tract. This remedy is sometimes used together with another antibiotic called clarithromycin (Biaxin) to treat stomach ulcers caused by Helicobacter pylori infection. This combination is sometimes used with a gastric acid reducer, called lansoprazole (Prevacid).

Urispas is an oral antispasmodic drug approved to prevent bladder spasms caused by urethral catheterization, infectious and /or inflammatory diseases of the urogenital system or neurological disorders.

Uroxatral - Alfuzosinis an active substance, as an antagonist of the α1 adenogenetic receptor, this drug relaxes the muscles of the prostate and the bladder. Used in the treatment of benign prostatic hyperplasia (BPH). Reduces pressure in the urethra and reduces resistance to urine flow, eases urination and eliminates dysuria.

Valif is a substitute drug for Levitra, with the active ingredient vardenafil, which treats the symptoms of erectile dysfunction or impotence in men and increases libido in women.

Valsartan Tablets 160 Mg is used to treat high blood pressure and heart failure. Lowering blood pressure helps to prevent future heart attacks and stroke. This medicine is also effective in preserving kidney function in patients with diabetes.

Valtrex is an antiviral. The active substance - valaciclovir - penetrates into the affected cell, interacts with enzymes, is embedded in the DNA of the pathogen. It is active against Herpes Simplex, Cytomegalovirus, Varicella-Zoster, Epstein-Barr, HHV-6 (herpes simplex type 6).

Vantin - combined preparation, based simultaneously on 2 active substances: Cefpodoxime Proxetil. It belongs to the third generation of cephalosporins. Used to treat acute otitis media, tonsilitis, pharyngitis, respiratory tract infections, such as pulmonary pneumonia and chronic bronchitis.

Vasotec- an antihypertensive drug based on the action of the active ingredient Enalapril, whose mechanism of action is associated with inhibition of the activity of the angiotensin-converting enzyme, leading to a decrease in the formation of the vasoconstrictor factor - angiotensin II and simultaneously to the activation of the formation of kinin and prostacyclin possessing a vasodilating action.

Vastarel - the main substance of the drug is trimetazidine, which is used for the prevention of angina attacks in IHD, as well as in vertigo caused by violations of cerebral circulation, Meniere's disease, noise in the ears. It is believed that the beneficial effect of trimetazidine in myocardial ischemia is mainly associated with its antioxidant and antihypoxic properties and cytoprotective effects on the function of cardiomyocytes.

Ventolin is a medicament for eliminating asthma attacks (bronchial) and other reversible diseases with bronchial obstruction.

The main active substance is salbutamol.

Ventolin is a medicament for eliminating asthma attacks (bronchial) and other reversible diseases with bronchial obstruction.

The main active substance is salbutamol.

Verapamil is a calcium channel blocker, it treats high blood pressure relaxing and widening blood vessels.

Vermox - anthelminthic drug of a wide spectrum of action. The most effective for Enterobius vermicularis, Trichuris trichiura, Ascaris lumbricoides, Ancylostoma duodenale, Necator americanus, Strongyloides stercoralis, Taenia solium, Echinococcus granulosus, Echinococcus multilocularis, Trichinella spiralis, Trichinella nativa, Trichinella nelsoni.

Causing an irreversible violation of glucose utilization, depletes glycogen stores in helminth tissues, interferes with the synthesis of cellular tubulin, and also inhibits the synthesis of ATP.

Viagra - Active ingredient - Sildenafil, 100 mg. Effect of "Viagra" is based on significant increase of blood stream to penis. Begins to work in 30 minutes, the effect lasts for 4-5 hours. Most of men can take this generic viagra every day. Millions of men worldwide cannot be mistaken, choosing Viagra!

Viagra capsules - it is a familiar Viagra, produced in the form of capsules that accelerates the beginning of effect of the drug, after swallowing. It is a strong drug for improvement of male sexual activity. It is very popular among people who take it for increase of potentiality. The medicine improves erection. Considerably increases sex duration. It begins to work in 15 minutes after taking and keeps efficiency within the next 6 - 7 hours

Viagra Gold - Active ingredient - Sildenafil, 200 mg. Now you can save money, taking a half or a quarter of a tablet. It is especially convenient for those men who take viagra every day.

Viagra Oral Jelly - a new formula of the drug Viagra. Sildenafil - 100 mg. It is prescribed for men with a weak potentiality. Helps to recover libido and to improve sexual activity. Accelerates process of excitement of reproductive system. It makes erection brighter. Considerably increases duration of sexual intercourse. Besides, drug has various pleasant tastes, it is convenient to carry in a pocket or in a purse. Hurry to try it!

Viagra Plus is the latest form of the medical treatment which is known worldwide. The formula is intensified by active medicinal plants, causing a boundless feeling of potentiality, unlimited desire and infinite lasting. The ginseng is one of the main ingredients of Viagra Plus, which carries out stimulation and increases endocrine activity in an organism, strengthens metabolism and facilitates cordial activity, helping thereby an arterial flow of blood, stimulating think-tanks and is promoted also by simplification of functioning of the central nervous system. Erection, sexual desire, success of sexual intercourse are guaranteed. From 400 mg of Viagra Plus - 50 mg make sildenafit, the remained 350 mg are ginseng and vitamins.

Viagra Professional - Advantage of Professional Viagra from usual Viagra is that it works twice longer (6 - 8 hours) and has a stronger effect. Strengthens desire, improves brightness of sexual feelings and increases duration of sexual intercourse.

Viagra Soft Flavored - chewing tablet viagra, which has a mint taste and differs from usual viagra by mode of administration and speed of effect. Unlike usual viagra - Viagra Soft Flavored should be resolved or chewed. So at administration of drug it is possible to take alcohol and greasy food that is not recommended at taking of any other type of viagra. The effect of Viagra Soft Flavored comes in 30 minutes after reception, and lasts for 4 hours.

Viagra Soft Tabs - chewable tablets, containing 100 mg of a sildenafil. Difference of Viagra Software from usual Viagra is that its action begins much quicker. Viagra Software is chewed and easily dissolved under the tongue that allows to receive the result in 10-15 minutes.

Viagra Super Active - an innovative formula of drug for treatment of erectile dysfunction. Drug is produced in gelatin capsules that allows to avoid emergence of heartburn or other unpleasant feelings in a stomach. Sildenafil Super Active also has a number of advantages. It is soaked quicker and works longer. The principle of action is identical with ordinary Sildenafil. Each capsule contains about 100 mg of active ingredient. That is quite enough for any man.

Viagra with Dapoxetine 100mg - Action of Sildenafil is based on significant increase of blood flow to penis. Dapoxetine action allows to extend the time interval from the beginning of the act till orgasm in 4 times. Therefore sex after taking of combined drug - Viagra with Dapoxetine will be bright and long that will remain in memory of any girl forever!

is given to patients for treating severe acne that do not respond to other medicines

Viagra with Duloxetine 100mg - one of the modern developments of physicians in the field of prevention and treatment of early ejaculation and extension of sexual contact. It was first produced in 2010 by Sunrise Remedies under the name Malegra DXT and in 3 years gained authority of doctors and trust of men of various nationalities. This drug contains two powerful active agents: Sildenafil (active ingredient of the drug Viagra) and Duloxetine (active ingredient of the drug Cymbalta). Action of Sildenafil, active agent of the drug Viagra, is known long ago and, most likely, does not need detailed description. Duloxetine-antidepressant with a soft action which is also used for prevention of early ejaculation. The combination of these two components in Malegra DXT allows to reach an excellent effect: to relax and concentrate only on sex, to reach a stable erection and to spend more time with a lady than usually.

Viagra with Fluoxetine - drug of new generation from the Indian pharmaceutical company Sunrise Remedies which called it Malegra FXT. It comprises two operating active agents: Sildenafil citrate and Prozac. Such combination of components effectively recovers potentiality and extends sexual intercourse by 3-4 times. But, besides, due to maintenance of Fluoxetine, Malegra FXT is a soft antidepressant and helps to remove stress and fatigue, to overcome nervousness and relax. After Malegra taking the man aquiress confidence in sexual drive, stress and anxiety disappears.

Voltaren has various forms of release but the topical gel is the most popular. The use of Voltaren gel leads to a reduction in edema of the tissues, pain and a reduction in the recovery time of the functions of damaged joints, ligaments, tendons and muscles.

The drug reduces the severity of acute pain an hour after its application. Due to the water-alcohol basis, this topical remedy also has a local anesthetic and cooling effect.

Voveran is one of the analgesic agents used mostly in the therapy of different painful conditions. The main indications for use of this anti-inflammatory medicine include arthritis, muscle pain, and migraines of different origin. The treatment of other pain syndromes may also require the use of this drug upon the therapist’s consideration. This is a non-steroidal medicine, which expands the spheres of its possible use in comparison with steroidal drugs, most notably in late-middle-aged people. The pills are not habit-forming; however, the misuse, as well as the long-term course of treatment, is prohibited.

Voveran SR is the special formulation of Voveran, developed for the suspended release of its active ingredients and, consequently, a prolonged period of action. Apart from this feature, it has no notable characteristics differentiating it from the original medicine – an analgesic that provides satisfying results in the treatment of moderate pain syndromes. It helps with a wide range of painful conditions allowing patients to stop the pain before it grows stronger or control it in case of chronic joint diseases. In general, the new form provides better results in particular in the treatment of prolonged pain.

Xalatan is a chemical analog of the hormone prostaglandin. It is a topical agent available in the form of eye drops with a concentration of latanoprost 50 mcg/ml. Its mode of action is similar to the one of its natural equivalent – the drug increases the flow of intraocular fluid from the hypertensive eyeball. As a result, the pressure in the eyeball slowly decreases. Since this symptom frequently accompanies various eye diseases, Xalatan is often prescribed in combination with other medicines. Today, this drug is among the high-priority agents in the treatment of such an ubiquitous disease as glaucoma.

Xeloda is a cytostatic drug. The drug is used for the treatment of patients with metastatic or locally advanced breast cancer, including after an ineffective chemotherapy course, which included anthracycline drugs and taxanes, and also if the patient has contraindications to anthracyclines.

Xenical - a powerful, specific and reversible inhibitor of gastrointestinal lipases, which has a long-lasting effect. Its therapeutic effect is carried out in the lumen of the stomach and small intestine and consists in the formation of a covalent bond with the active serine portion of the gastric and pancreatic lipases. The inactivated enzyme at the same time loses the ability to break down food fats coming in the form of triglycerides, to sucking free fatty acids and monoglycerides. Since uncleaved triglycerides are not absorbed, the resulting decrease in the intake of calories into the body leads to a decrease in body weight. Thus, the therapeutic effect of the drug is carried out without absorption into the systemic circulation.

Yasmin tablets are used to establish a reliable contraception provided that they are taken in accordance with the strict daily regimen. The mode of action is based on the impact of ethinyl estradiol and drospirenone – synthetic compounds substituting naturally produced hormones. Similarly to other hormonal contraceptives, Yasmin should be taken with great care: patients with hyperkalemia or with the history of breast cancer must avoid using the pills. Any side effects potentially indicating hormonal changes because of endocrine modulation should be instantly reported. However, the frequency of adverse reactions associating with the pills does not exceed the low-end threshold.

Zanaflex - muscle relaxant with the basic component tizanidine hydrochloride.

It is used to help loosen some muscles of your body. It relieves muscle spasms, which are the consequences of multiple sclerosis or spinal injuries.

Zantac - ranitidin - the drug is intended for the treatment of duodenal ulcers, benign gastric ulcer, postoperative ulcer, reflux esophagitis, Zollinger-Ellison syndrome, epigastric or chest pain. The administration of ranitidine is indicated in cases where a decrease in gastric secretion and a decrease in the production of hydrochloric acid is desirable, for the prevention of gastrointestinal bleeding, for the prevention of recurrence of bleeding in patients with bleeding ulcers of the stomach and duodenum, before general anesthesia in patients with a presumed risk of aspiration of acidic stomach contents (Mendelssohn syndrome), especially in women during childbirth delivery clashes.

Zebeta is a beta-blocker that affects the heart and blood flow. The drug is used to treat hypertension (high blood pressure)

Zenegra is a generic Sildenafil-containing medicine intended for use in urology – for the most part in the treatment of erectile dysfunctions of different origin. The drug provides regulation of the enzymic activity of the specific phosphodiesterase and releases nitric oxide that provides the muscle-relaxing effect. The active ingredient also maintains a certain level of blood pressure in the penis, providing a proper erectile response. The usual effect lasts no less than 4 hours; however, some patients report 18 and more hours of increased sexual arousal.

Zerit - treatment of infection caused by HIV, with severe clinical manifestations and ineffectiveness or intolerance of zidovudine, and other antiretroviral drugs. The nucleoside analogue of thymidine is phosphorylated by cellular enzymes to its active form - stavudine triphosphate. Suppresses reverse transcriptase of HIV, cellular DNA polymerases (beta and gamma), inhibits the synthesis of viral and mitochondrial DNA. It is active against HIV-1.

Zestoretic - tablets containing 12,5Mg of Hydrochlorothiazide and 10Mg of Lisinopril, as active ingredients. It is hypotensive, vasodilating, natriuretic, cardioprotective medical preparation.The drug is used to treat arterial hypertension, also in order to reduce the risk of cardiovascular disease and mortality in patients with hypertension and left ventricular hypertrophy, manifesting cumulative reduction in the incidence of cardiovascular death, incidence of stroke and myocardial infarction.

Zestril is an angiotensin-converting enzyme inhibitor (ACE). It works by relaxing the blood vessels. This helps lower blood pressure. It is used in the treatment of high blood pressure, alone or in conjunction with other medicines.

Zetia contains ezetrol as an active ingredient, which is a selective representative of a new class of lipid-lowering drugs that reduce the absorption of cholesterol in the intestine, including cholesterol from plant fats.

Zhewitra 20 mg is made of Sunrise remedies which is a generic pill of the patent medicine Levitra. It contains Vardenafil HCL in the composition of 20 mg. In India, the sunrise cure is a fast-growing manufacturer, exporter & provider of Pharmaceutical and Herbal Formulations including Herbal Remedies, Cosmetics & Ayurvedic devising.

It also deals in Allopathic formulations in the form of pills, medicine, water, and Topical sections as per international acceptance levels.

Zithromax - antibiotic of a wide spectrum of action. Antibiotic-azalide, a representative of a new subgroup of macrolide antibiotics. In the focus of inflammation it has a bactericidal effect. For the active ingredient of Zithromax, Azithromycin, all the gram-positive cocci (except those bacteria which are resistant to erythromycin) are susceptible.

Zocor is indicated to reduce mortality due to coronary artery disease. It is prescribed for the reduction of risk of serious vascular and coronary complications: non-fatal myocardial infarction, coronary death, stroke; revascularization operations. Designed to reduce the risk of the need for coronary blood flow restoration; rot reduce the risk of the need for surgical intervention to restore peripheral blood flow and other types of non-coronary revascularization; to reduce the risk of hospitalization in connection with attacks of angina pectoris; to decrease in the elevated level of total cholesterol, LDL cholesterol, triglycerides. apolipoprotein B; for increasing HDL cholesterol in patients with primary hypercholesterolemia, including heterozygous familial hypercholesterolemia.

is given to patients for treating severe acne that do not respond to other medicines

Zoloft is an antidepresant stopping the reuptake of serotonin, which is performed by the neurons that isolated it. As a result, the concentration of the neurotransmitter increases in the synaptic cleft and the main cause of depressive states, the serotonin deficiency, is eliminated.

Zovirax in the form of a cream for external use is prescribed for the treatment of infections of the skin and mucous membranes caused by the herpes simplex virus type 1 and 2, including herpes lips. Eye ointment is used for keratitis caused by the herpes simplex virus type 1 and 2. Zovirax inside and in the form of a solution for infusion is used in the presence of herpes zoster and chicken pox;

Indications for taking Zovirax in the form of tabletsis a:treatment of infections of the mucous membranes and skin caused by the herpes simplex virus type 1 and 2, including genital herpes; treatment of patients with severe immunodeficiency (mainly, with the expanded clinical picture of AIDS, with HIV infection), who underwent bone marrow transplantation.

Zudena is another representative of the PDE5 inhibitors ubiquitously used in contemporary urology. It is commonly used for the therapy and prevention of erectile dysfunction. The pills contain udenafil – a reverse inhibitor of the phosphodiesterase-5, which is responsible for filling the penis with blood. This active ingredient has a range of recently introduced advantages the most notable of which are more rapid absorption (30-60 minutes) and increased half-life (starting from 10 to 12 hours, which leads to a 24-hour period of activity). The medicine may be prescribed not only for symptomatic but also for a long-term treatment.

Any dependence of the body on external influences is considered as human weakness and drug addiction. Perhaps one of the most common is nicotine addiction. Zyban helps to overcome it.

Zyloprim is a tablet the effect of which appears due to the mechanism of action of its basic component called Allopurinol. This medicine is prescribed as a treatment of hyperuricemia, primary and secondary gout, urolithiasis with the formation of urinary calculi, hemoblastoma, cytostatic and radiation therapy of tumors, psoriasis, traumatic toxicosis. It is used as a corticosteroid therapy for the prevention of urinary acid nephropathy, malignant neoplasms and congenital disorders of purine metabolism in children.

Zyprexa is an antipsychotic drug used mainly to treat severe mental conditions, most notably schizophrenia. This oral medication normalizes the balance of chemical compounds in the brain, especially when used in combination with other antipsychotics. The active ingredient, which is a ligand for serotonin and dopamine receptors, provides also a selective impact on the functioning of the limbic system. The target group of the drug is not limited to the cases with extra severity – the pills may be prescribed for people with moderate mood or nervous conditions as well.

is given to patients for treating severe acne that do not respond to other medicines